Genome Maintenance Meeting 2
Transformation and DNA repair
Genome repair and consequences for microbial genome stability / instability, fitness for survival and virulence
September 6-9, 2003
Saturday September 6
15:00 → Registration
18:00 Opening lecture
Richard Moxon, Oxford, UK: "Adaptive behaviour of bacterial pathogens"
Reception in the Rikshospitalet glass mall
Sunday September 7
Session 1 - DNA repair
9:00 Philip C. Hanawalt, Stanford, USA: "Genomic stress responses in Escherichia coli: What can we generalize to other cellular systems?"
9:50 Pål Falnes, Oslo, Norway: "Repair of DNA and RNA by AlkB mediated oxidative demethylation "
10:30 Coffee break
11:00 Robert Fuchs, Strasbourg, France: "Involvement of multiple DNA polymerases during translesion synthesis"
11:45 Martin Marinus, Boston, USA: "The influence of Dam methylation on pathogenesis, DNA repair and chromosome structure in E. coli"
Session 2 - Genome instability and microbe-host interactions
13:30 Sebastian Suerbaum, Hannover, Germany: " Frequent genetic changes during long-term colonization by Helicobacter pylori "
14:15 Ivan Matic, Paris, France: "Ecological, physiological and genetic determinants of stress-induced mutagenesis in bacteria"
15:00 Brigitte Gicquel, Paris, France: "Epidemic strains of Mycobacterium tuberculosis carry mutations in putative mutator genes"
15:45 Coffee break
Session 3 - Transformation (1)
16:15 David Dubnau, New York, US: "Mechanism of DNA uptake by competent Bacillus subtilis"
17:00 Anne Britt Kolstø, Oslo, Norway: "Bacillus cereus and B. thuringensis genome dynamics
19:30 Bus transport
20:00 Festive dinner at Holmenkollen Park Hotell
Monday September 8
Session 4 - Transformation (2)
9:00 Jean-Pierre Claverys, Toulouse, France: "Fate of incoming single strands in transformation of Streptococcus pneumoniae"
9:45 Donald A. Morrison, Chicago, USA: "Competence for genetic transformation in Streptococcus pneumoniae: genes and regulatory pathways downstream of the competence pheromone".
10:30 Leiv Sigve Håvarstein, Ås, Norway: "Competence induced release of DNA from Streptococcus pneumoniae"
11:00 Coffee break
Session 5 - Consequences of transformation
Convenor: Leiv Sigve Håvarstein
11:30 Regine Hakenbeck, Kaiserslautern, Germany: "Mosaic genes and mosaic chromosomes - the definition of the pneumococcus"
12:15 Brian Spratt, London, UK: "The relative contributions of recombination and point mutation to the diversification of bacterial clones"
Session 6 - Genome dynamics (1)
14:00 Igor Stojiljkovic, Atlanta, USA: "Mismatch repair affects neisserial epidemiology and virulence by creating hypermutator strains"
14:45 Janne Cannon, Chapel Hill, US: "Do defects in mismatch repair influence gonococcal virulence?"
15:30 Coffee break
16:00 Mike Koomey, Oslo, Norway: "Components of DNA binding and uptake in transformation linked to Neisseria Type IV pili"
16:45 Dan Andersson, Stockholm, Sweden: "Amplification-mutagenesis: an explanation for hypermutagenesis and stress-induced mutability of the lac operon"
Tuesday September 9
Session 7 - Genome dynamics (2)
9:00 Chris Bayliss, Oxford, UK: "The role of tetranucleotide repeats, mismatch repair and phase variation of H. influenzae and N. meningitidis"
9:45 Jesus Blázquez, Madrid, Spain: "Hypermutator strains of Pseudomonas aeruginosa, Escherichia coli and Mycobacterium tuberculosis"
10.30 Coffee break
11:00 Stuart Hill, Chicago, US: "Recombination in Neisseria gonorrhoeae: Unique features and consequences for surface exposed components"
11:45 Torbjørn Rognes, Oslo, Norway: "The DNA Repair Gene Database - Exploring cross-organism gene relationships"
Session 8 - DNA transfer
13:00 Matt Waldor, Boston, US: "Phage transfer of the cholera toxin genes"
13:45 Lisa Valentine, Basel, Switzerland: "The conquest of plants by Agrobacterium"
14:30 Coffee break
15:00 Staffan Normark, Stockholm, Sweden: "Bacterial plasticity in the interaction with the host innate immune system"
15:45 Closing remarks
16:00 Course exam (for doctoral students)
The posters will be accessible throughout the meeting
Last updated 2003-08-22 by SAF and TD.