Programme

Wednesday, June 17th 

13:00 Lunch
   
13:00 Registration opens
   

Session I: RNA Metabolism et al

  Chair: Arne Klungland
   
15:00 Arne Klungland, Magnar Bjørås, Yungui Yang
  Welcome and introduction to session I
   
15:10 Mutsuo Sekiguchi
  Molecular tactics to escape treat of oxidative RNA damage
   
15:35 Nima Mosammaparast
  Ubiquitin-dependent mechanisms of alkylation repair regulation
   
16:00 Hilde Nilsen 
  DNA and RNA quality control by SMUG1
   
16:25 Ingrun Alseth
  Human Endonuclease V as an inosine specific ribonulclease
   
16:40 Coffee
   
16:50 Yungui Yang
  Decipher the biological role of reversible RNA modifications
   
17:15 Roger Woodgate
  Utilization of Y-family polymerase steric gate mutants to uncover novel mechanisms of ribonucleotide repair
   
17:40 Hanna Delago
  The DNA repair factor SNEVhPrp19/hPso4 regulates cellular and organismal life span and promotes adipogenic differentiation
   
17:55 Simon Bekker-Jensen
  SCAI interacts with 53BP1 to promote heterochromatin-associated DNA repair and maintain genomic stability in vivo
   
18:10 Tapas
   

Session II: Evening Keynote Presentations

  Chair: Magnar Bjørås
   
19:00 Miroslav Radman
  Anti-oxodant protection and radiation resistance
   
19:30 Hans Krokan
  All the things U are
   
20:00 Matthias Meyer
  Post-mortem DNA damage – challenges to ancient DNA research
   

Thursday, June 18th 

07:30 Breakfast
   

Session I: RNA Metabolism et al

  Chair: Arne Klungland
   
09:00 Chuan He
  Oxidative demethylation of RNA in Biological regulation
   

Session III: Translesion synthesis and mutagenesis associated processes

  Chair: Richard Wood
   
09:25 Richard Wood
  Suppression of Chromosome instability by DNA polymerase Q
   
09:50 Graham Walker
  Translesion DNA polymerases: From cancer chemotherapy to bactericidal antibiotics
   
10:15 Robert Fuchs
  Damaged DNA Replication: how lesion tolerance pathways are interconnected in vivo
   
10:40 Coffee break
   
11:10 Arthur Grollman
  Signature mutation of a novel human carcinogen
   
11:35 Lawrence A. Loeb
  The Mutator Phenotype in Human Cancer
   
12:00 Eugenia Dogliotti
  Mitochondrial dysfunction in DNA repair defective disorders: mechanisms and pathological relevance 
   
12:25 Matthias Altmeyer
  DNA strand breaks trigger phase transitions of intrinsically disordered proteins
   
12:40 Françoise Dantzer
  Poly(ADP-ribose polymerase 3 (PARP3) in epithelial to mesenchymal transition
   
13:00 Lunch
   

Session IV: DNA repair and disease

  Chair: Eugenia Dogliotti 
   
14:00 Zhao-Qi Wang 
  Life without proper DNA repair
   
14:25 Jan H. J. Hoeijmakers
  The overwhelming role of DNA damage in the process of ageing
   
14:50 Alan Lehmann
  Genetic and clinical heterogeneity in the XP population in the UK
   
15:15 Francesco Blasi
  Prep1 (pKnox1) tumor suppressor prevents DNA replication stress, DNA damage and in cancer
   
15:40 Coffee break/waffles
   
16:10 Thomas Helleday
  Targeting DNA repair for cancer treatment: from PARP to MTH1 inhibitors
   
16:35 Ketan J Patel 
  Why mammals require DNA crosslink repair
   
17:00 Peter Karran 
  Protein oxidation and human DNA repair
   
17:25 Alan Tomkinson
  Targeting cancer cell mitochondria
   
17:50 Posters and refreshments
   
19:30 Dinner
   

Friday, June 19th 

07:30 Breakfast
   

Session V: DNA strand breaks and human disease

  Chair: Stephen West 
   
09:00 Stephen West
  Mechanism of Holliday junction resolution by GEN1
   
09:25 Keith Caldecott
  DNA Strand Break Repair and Human Genetic Disease
   
09:50 Steve Jackson
  DNA double-strand break repair: a 20/20 vision
   
10:15 Valentyn Oksenych
  Deficiency of Ku70 rescues early postnatal lethality of XLF/DNA-PKcs double deficient mice
   
10:30 HaiLin Wang
  ATPase activity-regulated and unbound nucleotide sites-predominated RecA nucleofilaments are the active form for accurate homology recombination
   
10:45 Coffee 
   

Session VI: The transcription machinery

  Chair: Jean Marc Egly
   
11:00 Jean Marc Egly
  Involvement of NER factors in transcription
   
11:25 Moshe Yaniv 
  Chromatin remodeling: from transcription to cancer
   
11:50 Philip Hanawalt
  Consequences of arrested transcription - the good, the bad and the ugly 
   
12:15 Jesper Svejstrup
  The transcription-related DNA damage response
   
12:40 Joanna Timmins
  Structural and functional studies of NER and HR processes in the extreme-radiation resistant bacterium D. radiodurans
   
13:00 Lunch
   
  Afternoon/evening free for sightseeing
   

Saturday, June 20th 

07:30 Breakfast
   

Session VII: DNA repair and the cell cycle

  Chair: Jiri Bartek
   
09:00 Jiri Bartek
  DNA damage signalling: Mechanistic insights and relevance for cancer
   
09:25 Ian D. Hickson
  How unfinished business from S-phase affects mitosis
   
09:50 Marco Foiani
  Mechanisms controlling the integrity of replicating chromosomes
   
10:15 Xinzhi (Xavier) Xu 
  Regulation of CLASPIN-mediated CHK1 activation
   
10:40 Fabrizio d'Adda di Fagagna
  The role of RNA in the DNA damage response
   
11:05 Coffee 
   

Session VIII: Mismatch repair

  Chair: Josef Jiricny
   
11:25 Josef Jiricny
  Multifaceted mismatch repair
   
11:50 Margherita Bignami
  Role of MUTYH in human cancer
   
12:15 Bruce Demple
  When DNA repair goes wrong: Formation and resolution of BER-generated protein-DNA crosslinks with oxidative lesion
   
12:30 Bernd Kaina
  DNA repair and ROS sensitivity of monocytes, macrophages and other immunocompetent cells
   
12:45 Manju Hingorani
  A dynamic process of mismatch recognition leads to a stalled MutS-MutL complex for initiation of DNA repair
   
13:00 Lunch
   

Session IX: Base excision repair (et al)

  Chair: Primo Schär
   
14:00 Primo Schär
  Active DNA demethylation by DNA repair - What is it good for?
   
14:25 Grigory Dianov
  DNA base excision repair
   
14:55 Geir Slupphaug
  Novel aspects of genomic uracil induction and processing
   
15:20 Coffee
   
15:40 Cristina Rada
  Uracil excision in the immune response 
   
16:05 Eric Gilson
  How telomeres exert their influence genome-wide
   

Session X: EMBO editor

  Chair: Arne Klungland
   
16:30 Bernd Pulverer
  Transparent Publishing: How to Share Reproducible Data
   
17:20 Break 
   
18:45 Champagne
   

Session XI: Tomas Lindahl

   
19:00 Tomas Lindahl
  Instability, decay and repair of DNA
   
20:00 Gala dinner
   

Sunday, June 21th 

07:30 Breakfast and departure